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There is some evidence, albeit not of a statistically significant character, that tumors with less atypical cytologic characteristics behave in a more indolent fashion than those with overtly malignant nuclear features

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Front Pharmacol 15:1401961 Koshkin V et al (2004) The Characterization of Mitochondrial Permeability Transition in Clonal Pancreatic -Cells: MULTIPLE MODES AND REGULATION*